PuSH - Publication Server of Helmholtz Zentrum München: Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Papaioannou, N.E.* ; Salei, N.* ; Rambichler, S.* ; Ravi, K.* ; Popovic, J.* ; Küntzel, V.* ; Lehmann, C.H.K.* ; Fiancette, R.* ; Salvermoser, J.* ; Gajdasik, D.W.* ; Mettler, R.* ; Messerer, D.* ; Carrelha, J.* ; Ohnmacht, C. ; Haller, D.* ; Stumm, R.* ; Straub, T.* ; Jacobsen, S.E.W.* ; Schulz, C.* ; Withers, D.R.* ; Schotta, G.* ; Dudziak, D.* ; Schraml, B.U.*

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Nat. Commun. 12:464 (2021)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves. Developmentally distinct cDC2 in early life, despite being distinguishable by fate mapping, are transcriptionally and functionally similar. cDC2 in early and adult life, however, are exposed to distinct cytokine environments that shape their transcriptional profile and alter their ability to sense pathogens, secrete cytokines and polarize T cells. We further show that cDC2 in early life, despite being distinct from cDC2 in adult life, are functionally competent and can induce T cell responses. Our results thus highlight the potential of harnessing cDC2 for boosting immunity in early life.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 2041-1723

e-ISSN 2041-1723

Journal Nature Communications

Quellenangaben Volume: 12, Issue: 1, Article Number: 464

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Allergy Research (IAF)

Grants SFB914
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Emmy Noether Grant
DFG
DZHK (German Centre for Cardiovascular Research)
BMBF (German Ministry of Education and Research)
Agency national research (ANR)/German Research Foundation program
ERC Starting Grant