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Rühlemann, M.C.* ; Hermes, B.M.* ; Bang, C.* ; Doms, S.* ; Moitinho-Silva, L.* ; Thingholm, L.B.* ; Frost, F.* ; Degenhardt, F.* ; Wittig, M.* ; Kässens, J.* ; Weiss, F.U.* ; Peters, A. ; Neuhaus, K.* ; Völker, U.* ; Völzke, H.* ; Homuth, G.* ; Weiss, S.* ; Grallert, H. ; Laudes, M.* ; Lieb, W.* ; Haller, D.* ; Lerch, M.M.* ; Baines, J.F.* ; Franke, A.*

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

Nat. Genet. 53, 147–155 (2021)

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The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory^1,2, neurologic³ and neoplastic diseases⁴. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain^5-11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition¹¹. In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with Bacteroides and Faecalibacterium spp. Mendelian randomization analysis suggests causative and protective effects of gut microbes, with clade-specific effects on inflammatory bowel disease. This holistic investigative approach of the host, its genetics and its associated microbial communities as a 'metaorganism' broaden our understanding of disease etiology, and emphasize the potential for implementing microbiota in disease treatment and management.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Non-secretor Status; Host Genetics; Health; Diversity; Disease; Linking; Risk

ISSN (print) / ISBN 1061-4036

e-ISSN 1546-1718

Journal Nature Genetics

Quellenangaben Volume: 53, Issue: 2, Pages: 147–155

Publisher Nature Publishing Group

Publishing Place New York, NY

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)

Grants EC | Directorate-General for Employment, Social Affairs and Inclusion | European Social Fund (Fondo Social Europeo)
Deutsche Forschungsgemeinschaft (German Research Foundation)