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Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
Nat. Commun. 12:426 (2021)
Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in diabetes. In streptozotocin-induced diabetic mice the Pomc promoter is repressed due to increased binding of NF-kB p50 subunit, leading to a loss in basal POMC level in peripheral nerves. Decreased POMC levels are also observed in peripheral nervous system tissue from diabetic patients. The antinociceptive pathway mediated by POMC is further impaired due to lysosomal degradation of μ-opioid receptor (MOR). Importantly, the neuropathic phenotype of the diabetic mice is rescued upon viral overexpression of POMC and MOR in the sensory ganglia. This study identifies an antinociceptive mechanism in the sensory ganglia that paves a way for a potential therapy for diabetic neuropathic pain.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Proopiomelanocortin Gene-expression; Peripheral Sensory Neurons; Factor-kappa-b; Opioid Receptor Phosphorylation; Kinase-c Isoforms; Beta-endorphin; Metabolic Dysfunction; Channel Function; Met-enkephalin; Ion-channel
Language
english
Publication Year
2021
HGF-reported in Year
2021
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 12,
Issue: 1,
Article Number: 426
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-251
Grants
Projekt DEAL
WOS ID
WOS:000625194400001
WOS ID
WOS:000611511500004
Scopus ID
85099593508
PubMed ID
33462216
Erfassungsdatum
2021-02-08