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Pawliczek, D. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Graw, J. ; Dalke, C.

Ionising radiation causes vision impairment in neonatal B6C3F1 mice.

Exp. Eye Res. 204:108432 (2021)
Postprint DOI PMC
Open Access Green
Ionising radiation interacts with lenses and retinae differently. In human lenses, posterior subcapsular cataracts are the predominant observation, whereas retinae of adults are comparably resistant to even relatively high doses. In this study, we demonstrate the effects of 2 Gy of low linear energy transfer ionising radiation on eyes of B6C3F1 mice aged postnatal day 2. Optical coherence tomography and Scheimpflug imaging were utilised for the first time to monitor murine lenses and retinae in vivo. The visual acuity of the mice was determined and histological analysis was conducted. Our results demonstrated that visual acuity was reduced by as much as 50 % approximately 9 months after irradiation in irradiated mice. Vision impairment was caused by retinal atrophy and inner cortical cataracts. These results help to further our understanding of the risk of ionising radiation for human foeti (∼ 8 mo), which follow the same eye development stages as neonatal mice.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cataracts ; Eye Lens ; Ionising Radiation ; Oct ; Retina ; Scheimpflug Imaging ; Visual Acuity
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0014-4835
e-ISSN 1096-0007
Journal Experimental Eye Research
Quellenangaben Volume: 204, Issue: , Pages: , Article Number: 108432 Supplement: ,
Publisher Elsevier
Publishing Place 24-28 Oval Rd, London Nw1 7dx, England
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Institute of Metabolism and Cell Death (MCD)
POF-Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
30203 - Molecular Targets and Therapies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-002
G-500600-001
G-506900-001
Grants H2020 Euratom
Taiwan Mouse Clinic
DOI 10.1016/j.exer.2020.108432
WOS ID WOS:000633033700001
Scopus ID 85099609520
PubMed ID 33454312
Erfassungsdatum 2021-03-24
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