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Lenk, L.* ; Carlet, M. ; Vogiatzi, F.* ; Spory, L.* ; Winterberg, D.* ; Cousins, A.* ; Vossen-Gajcy, M.* ; Ibruli, O.* ; Vokuhl, C.* ; Cario, G.* ; El Ayoubi, O.* ; Krämer, L.* ; Ritgen, M.* ; Brüggemann, M.* ; Häsler, R.* ; Schrappe, M.* ; Fuhrmann, S.* ; Halsey, C.* ; Jeremias, I. ; Hobeika, E.* ; Jumaa, H.* ; Alsadeq, A.* ; Schewe, D.M.*

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.

Comm. Biol. 4:73 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Pre-bcr; Risk; Involvement; Disease; Kinase
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Journal Communications Biology
Quellenangaben Volume: 4, Issue: 1, Pages: , Article Number: 73 Supplement: ,
Publisher Springer
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
Grants Children's Cancer and Leukaemia Group (CCLG)