PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Lenk, L.* ; Carlet, M. ; Vogiatzi, F.* ; Spory, L.* ; Winterberg, D.* ; Cousins, A.* ; Vossen-Gajcy, M.* ; Ibruli, O.* ; Vokuhl, C.* ; Cario, G.* ; El Ayoubi, O.* ; Krämer, L.* ; Ritgen, M.* ; Brüggemann, M.* ; Häsler, R.* ; Schrappe, M.* ; Fuhrmann, S.* ; Halsey, C.* ; Jeremias, I. ; Hobeika, E.* ; Jumaa, H.* ; Alsadeq, A.* ; Schewe, D.M.*

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.

Comm. Biol. 4:73 (2021)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.268
1.627
2
5
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Pre-bcr; Risk; Involvement; Disease; Kinase
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Journal Communications Biology
Quellenangaben Volume: 4, Issue: 1, Pages: , Article Number: 73 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-506600-001
Grants Children's Cancer and Leukaemia Group (CCLG)
DOI 10.1038/s42003-020-01591-z
WOS ID WOS:000609504900007
Scopus ID 85100107958
PubMed ID 33452446
Erfassungsdatum 2021-03-30
[➜Report correction]