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Genetically encodable materials for non-invasive biological imaging.
Nat. Mater. 20, 585–592 (2021)
Many questions in basic biology and medicine require the ability to visualize the function of specific cells and molecules inside living organisms. In this context, technologies such as ultrasound, optoacoustics and magnetic resonance provide non-invasive imaging access to deep-tissue regions, as used in many laboratories and clinics to visualize anatomy and physiology. In addition, recent work has enabled these technologies to image the location and function of specific cells and molecules inside the body by coupling the physics of sound waves, nuclear spins and light absorption to unique protein-based materials. These materials, which include air-filled gas vesicles, capsid-like nanocompartments, pigment-producing enzymes and transmembrane transporters, enable new forms of biomolecular and cellular contrast. The ability of these protein-based contrast agents to be genetically encoded and produced by cells creates opportunities for unprecedented in vivo studies of cellular function, while their amenability to genetic engineering enables atomic-level design of their physical, chemical and biological properties.
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Publication type
Article: Journal article
Document type
Review
Keywords
Contrast Agents; Mri Contrast; Gene-expression; Photoacoustic Tomography; Fluorescent Proteins; Going Deeper; Reporter; Ultrasound; Nanostructures; Evolution
ISSN (print) / ISBN
1476-1122
e-ISSN
1476-1122
Journal
Nature materials
Quellenangaben
Volume: 20,
Pages: 585–592
Publisher
Nature Publishing Group
Publishing Place
Basingstoke
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Insitute of Synthetic Biomedicine (ISBM)
Grants
Federation of European Biochemical Societies
German Research Foundation (DFG)
Natural Sciences and Engineering Research Council of Canada (NSERC)
Burroughs Wellcome Fund
Dana Foundation
Sontag Foundation
Pew Charitable Trusts
The David & Lucile Packard Foundation
Heritage Medical Research Institute
German Research Foundation (DFG)
Natural Sciences and Engineering Research Council of Canada (NSERC)
Burroughs Wellcome Fund
Dana Foundation
Sontag Foundation
Pew Charitable Trusts
The David & Lucile Packard Foundation
Heritage Medical Research Institute