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Does C-C motif chemokine ligand 2 (CCL2) link obesity to a pro-inflammatory state?
Int. J. Mol. Sci. 22:1500 (2021)
The mechanisms of how obesity contributes to the development of cardio-metabolic diseases are not entirely understood. Obesity is frequently associated with adipose tissue dysfunction, characterized by, e.g., adipocyte hypertrophy, ectopic fat accumulation, immune cell infiltration, and the altered secretion of adipokines. Factors secreted from adipose tissue may induce and/or maintain a local and systemic low-grade activation of the innate immune system. Attraction of mac-rophages into adipose tissue and altered crosstalk between macrophages, adipocytes, and other cells of adipose tissue are symptoms of metabolic inflammation. Among several secreted factors attract-ing immune cells to adipose tissue, chemotactic C-C motif chemokine ligand 2 (CCL2) (also de-scribed as monocyte chemoattractant protein-1 (MCP-1)) has been shown to play a crucial role in adipose tissue macrophage infiltration. In this review, we aimed to summarize and discuss the current knowledge on CCL2 with a focus on its role in linking obesity to cardio-metabolic diseases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adipokine ; Adipose Tissue ; Chemokine ; Inflammation ; Obesity
Language
english
Publication Year
2021
HGF-reported in Year
2021
ISSN (print) / ISBN
1661-6596
e-ISSN
1422-0067
Quellenangaben
Volume: 22,
Issue: 3,
Article Number: 1500
Publisher
MDPI
Publishing Place
Basel
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-506501-001
Grants
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
WOS ID
WOS:000615319100001
Scopus ID
85100264222
PubMed ID
33540898
Erfassungsdatum
2021-04-14