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A mouse model for microbeam radiation therapy of the lung.
Int. J. Radiat. Oncol. Biol. Phys. 110, 521-525 (2021)
Purpose: Radiation therapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiation therapy techniques is relatively short. Data from preclinical experiments suggest that synchrotron microbeam radiation therapy could be much better suited to control malignant brain tumors than current clinical concepts of radiation therapy. Even at peak doses of several hundred gray, the extent of functional deficits is low. Methods and Materials: We have developed the first mouse model to study the effects of microbeam irradiation in lung tissue. Results: Up to peak doses of 400 Gy, no acute adverse effects were seen. Conclusion: This model is well suited to explore the potential of microbeam radiation therapy in the treatment of lung cancer and the response of normal lung tissue and organs at risk.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Radiotherapy; Uniform
ISSN (print) / ISBN
0360-3016
e-ISSN
0360-3016
Quellenangaben
Volume: 110,
Issue: 2,
Pages: 521-525
Publisher
Elsevier
Publishing Place
Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Medicine (IRM)
Grants
Deutsche Forschungsgemeinschaft (DFG) , Germany