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Herker, E.* ; Vieyres, G.* ; Beller, M.* ; Krahmer, N. ; Bohnert, M.*

Lipid droplet contact sites in health and disease.

Trends Cell Biol. 31, 345-358 (2021)
Publ. Version/Full Text Article in press DOI PMC
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After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD–organelle contacts are important players in development and progression of disease.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Bscl2 ; Cide ; Nafld ; Rab18 ; Viral Replication Organelle ; Vps13; Hepatitis-c Virus; Endoplasmic-reticulum; Insulin Sensitivity; Vldl Secretion; Protein; Seipin; Gene; Er; Perilipin; Rab18
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Journal Trends in Cell Biology
Quellenangaben Volume: 31, Issue: 5, Pages: 345-358 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Cambridge
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Gerty Cori Programme, Medical Faculty, University of Munster, Germany
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
DFG Emmy Noether Programme
University of Dsseldorf, Germany
LOEWE Center DRUID (Novel Drug Targets against Povertyrelated and Neglected Tropical Infectious Diseases)
Deutsche Forschungsgemeinschaft