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Herker, E.* ; Vieyres, G.* ; Beller, M.* ; Krahmer, N. ; Bohnert, M.*

Lipid droplet contact sites in health and disease.

Trends Cell Biol. 31, 345-358 (2021)
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After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD–organelle contacts are important players in development and progression of disease.
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Publication type Article: Journal article
Document type Review
Keywords Bscl2 ; Cide ; Nafld ; Rab18 ; Viral Replication Organelle ; Vps13; Hepatitis-c Virus; Endoplasmic-reticulum; Insulin Sensitivity; Vldl Secretion; Protein; Seipin; Gene; Er; Perilipin; Rab18
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Journal Trends in Cell Biology
Quellenangaben Volume: 31, Issue: 5, Pages: 345-358 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-221
Grants Gerty Cori Programme, Medical Faculty, University of Munster, Germany
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
DFG Emmy Noether Programme
University of Dsseldorf, Germany
LOEWE Center DRUID (Novel Drug Targets against Povertyrelated and Neglected Tropical Infectious Diseases)
Deutsche Forschungsgemeinschaft
DOI 10.1016/j.tcb.2021.01.004
WOS ID WOS:000640703400004
Scopus ID 85100426318
PubMed ID 33546922
Erfassungsdatum 2021-04-14
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