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Trefzer, A.* ; Kadam, P.* ; Wang, S.H.* ; Pennavaria, S.* ; Lober, B.* ; Akçabozan, B.* ; Kranich, J.* ; Brocker, T.* ; Nakano, N.* ; Irmler, M. ; Beckers, J. ; Straub, T.* ; Obst, R.*

Dynamic adoption of anergy by antigen-exhausted CD4+ T cells.

Cell Rep. 34:108748 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Anergy ; Cd4 T Cells + ; Exhaustion ; Gene Expression ; Microarray ; T Cell Receptor ; Tolerance ; Transcriptomics ; Tuning; Chronic Viral-infections; Cutting Edge; Lymphocyte-activation; Dendritic Cells; B-cells; Tcr; Cd8; Transcription; Expression; Responses
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 34, Issue: 6, Pages: , Article Number: 108748 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Grants Helmholtz Alliance ``Aging and Metabolic Programming, AMPro''
German Research Council (Deutsche Forschungsgemeinschaft)