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The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
Cell Rep. 34:108742 (2021)
The Authors Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Compass Complex ; Dexamethasone ; Enhancers ; Genomics ; Glucocorticoid Receptor ; H3k4 Methylation ; Inflammation ; Macrophages ; Setd1a ; Transcription; Histone H3; Binding Protein; Methyltransferase Complex; Saccharomyces-cerevisiae; Chromatin Accessibility; Molecular Regulation; Set1 Complex; Phd Finger; R Package; Gene
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Journal
Cell Reports
Quellenangaben
Volume: 34,
Issue: 6,
Article Number: 108742
Publisher
Cell Press
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
ERC
DFG
DFG