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Then, C. ; Then, H.L.* ; Lechner, A. ; Thorand, B. ; Meisinger, C. ; Heier, M. ; Peters, A. ; Koenig, W.* ; Rathmann, W.* ; Scherberich, J.* ; Seissler, J.

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

Clin. Kidney J. 14, 205-211 (2021)
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Background: Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population. Methods: We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study, ages 62-81 years, at baseline and prospectively after a mean follow-up time of 6.5 years (n = 605) using logistic and linear regression models as well as receiver operating characteristics (ROC) analyses. Results: Cross-sectionally, sUmod was positively associated with eGFR (β = 0.31 ± 0.02 per higher standard deviation sUmod; P < 0.001) and inversely associated with the urinary albumin:creatinine ratio (β = -0.19 ± 0.04; P < 0.001) after adjustment for sex, age, body mass index, arterial hypertension, prediabetes and diabetes. After multivariable adjustment including baseline eGFR, sUmod was not associated with incident chronic kidney disease (CKD), defined as a decrease in eGFR <60 mL/min/1.73 m2 after 6.5 years of follow-up {odds ratio [OR] 1.02 [95% confidence interval (CI) 0.77-1.36] per higher SD sUmod} but was inversely associated with advanced CKD, defined as incident eGFR <45 mL/min/1.73 m2 [OR 0.64 (95% CI 0.42-0.98)]. The ROC showed no added predictive value of sUmod for kidney function decline in the fully adjusted model. Conclusions: Higher sUmod was inversely associated with progression to advanced kidney disease but does not provide additional predictive value for the development of CKD in elderly participants of the population-based KORA study.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Albuminuria ; Egfr ; General Community ; Serum Uromodulin; Tamm-horsfall Protein; Urinary Uromodulin; Umod Gene; Glycoprotein; Mutations; Disease; Health; Nephropathy; Expression; Mortality
ISSN (print) / ISBN 2048-8505
e-ISSN 2048-8513
Journal Clinical Kidney Journal
Quellenangaben Volume: 14, Issue: 1, Pages: 205-211 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Biomarker for the subclassification of T2DM (KKG-KDB)
Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Grants German Research Foundation
Deutsche Diabetes Gesellschaft
Ministry of Culture and Science of the state North Rhine Westphalia (Dusseldorf, Germany)
German Diabetes Center - Federal Ministry of Health (Berlin, Germany)
Clinical Cooperation Group Diabetes, Ludwig-Maximilians-University Munchen and Helmholtz Zentrum Munchen
Virtual Diabetes Institute (Helmholtz Zentrum Munchen)
State of Bavaria
Helmholtz Zentrum Munchen -German Research Center for Environmental Health - German Federal Ministry of Education and Research