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Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography.
Mol. Metab. 47:101184 (2021)
OBJECTIVE: Postprandial lipid profiling (PLP), a risk indicator ofcardiometabolic disease, is based on frequent blood sampling over several hours after a meal, an approach that is invasive and inconvenient. Non-invasive PLP may offer an alternative for disseminated human monitoring. Herein, we investigate the use of clinical Multispectral Optoacoustic Tomography (MSOT) for the non-invasive, label-free PLP via direct lipid-sensing in human vasculature and soft tissues. METHODS: Four (n = 4) subjects (3 females and 1 male, age: 28 ± 7 years) were enrolled in the current pilot study. We longitudinally measured the lipid signals in arteries, veins, skeletal muscles and adipose tissues of all participants at 30 min-intervalsfor 6 hours after the oral consumption of a high-fat meal. RESULTS: Optoacoustic lipid-signal analysis showed on average a 63.4% intra-arterial increase at ∼4 hours postprandially, a 83.9% intra-venous increase at ∼3 hours, a 120.8% intra-muscular increase at ∼3 hours and a 32.8% subcutaneous fat increase at ∼4 hours. CONCLUSION: MSOT provides the potential to study lipid metabolism that could lead to novel diagnostics and prevention strategies by label-free, non-invasive detection of tissue biomarkers implicated in cardiometabolic diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cardiovascular Risk ; Fat ; Hyperlipidemia ; Lipid Metabolism ; Metabolic Imaging ; Photoacoustics
ISSN (print) / ISBN
2212-8778
e-ISSN
2212-8778
Journal
Molecular Metabolism
Quellenangaben
Volume: 47,
Article Number: 101184
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
EC | European Research Council (ERC)
European Union’s Horizon 2020 research and innovation programme
Deutsches Zentrum fur Herz-Kreislauf-Forschung (German Center for Cardiovascular Research, DZHK)
BMBF (German Ministry for Education and Research)
European Union’s Horizon 2020 research and innovation programme
Deutsches Zentrum fur Herz-Kreislauf-Forschung (German Center for Cardiovascular Research, DZHK)
BMBF (German Ministry for Education and Research)