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Towards a systems-level understanding of mitochondrial biology.
Cell Calcium 95:102364 (2021)
Human mitochondria are complex and highly dynamic biological systems, comprised of over a thousand parts and evolved to fully integrate into the specialized intracellular signaling networks and metabolic requirements of each cell and organ. Over the last two decades, several complementary, top-down computational and experimental approaches have been developed to identify, characterize and modulate the human mitochondrial system, demonstrating the power of integrating classical reductionist and discovery-driven analyses in order to de-orphanize hitherto unknown molecular components of mitochondrial machineries and pathways. To this goal, systematic, multiomics-based surveys of proteome composition, protein networks, and phenotype-to-pathway associations at the tissue, cell and organellar level have been largely exploited to predict the full complement of mitochondrial proteins and their functional interactions, therefore catalyzing data-driven hypotheses. Collectively, these multidisciplinary and integrative research approaches hold the potential to propel our understanding of mitochondrial biology and provide a systems-level framework to unraveling mitochondria-mediated and disease-spanning pathomechanisms.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Functional Associations ; Integrative Analyses ; Mitochondrial System ; Multiomics Approaches
ISSN (print) / ISBN
0143-4160
e-ISSN
1532-1991
Journal
Cell calcium
Quellenangaben
Volume: 95,
Article Number: 102364
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
Grants
ExNet-0041-Phase2-3 ("SyNergy-HMGU") through the Initiative and Network Fund of the Helmholtz Association
Munich Center for Systems Neurology (SyNergy EXC 2145)
Munich Center for Systems Neurology (SyNergy EXC 2145)