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Associations between dog keeping and indoor dust microbiota.
Sci. Rep. 11:5341 (2021)
Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Endotoxin; Microorganisms; Determinants; Fungal; Life
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Journal
Scientific Reports
Quellenangaben
Volume: 11,
Issue: 1,
Article Number: 5341
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Grants
Kuopio Area Respiratory Foundation
Juho Vainio Foundation
Yrjo Jahnsson Foundation
Foundation for Pediatric Research
EVO/VTR-funding
Paivikki and Sakari Sohlberg Foundation
Finnish Cultural Foundation
Finnish Institute for Health and Welfare, Finland
Federal Ministry for Education, Science, Research and Technology
Helmholtz Zentrum Munich, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel
Academy of Finland
Academy of Finland as part of PROBIOM consortium
Juho Vainio Foundation
Yrjo Jahnsson Foundation
Foundation for Pediatric Research
EVO/VTR-funding
Paivikki and Sakari Sohlberg Foundation
Finnish Cultural Foundation
Finnish Institute for Health and Welfare, Finland
Federal Ministry for Education, Science, Research and Technology
Helmholtz Zentrum Munich, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel
Academy of Finland
Academy of Finland as part of PROBIOM consortium