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Open Access Green as soon as Postprint is submitted to ZB.
Liver inflammation and hepatobiliary cancers.
Trends Cancer 7, 606-623 (2021)
Immune regulation has an important role in cancer development, particularly in organs with continuous exposure to environmental pathogens, such as the liver and gastrointestinal tract. Chronic liver inflammation can lead to the development of hepatobiliary cancers, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), or combined HCC (cHCC)-CCA. In this review, we discuss the link between oxidative stress and the hepatic immune compartments, as well as how these factors trigger hepatocyte damage, proliferation, and eventually cancer initiation and its sustainment. We further give an overview of new anticancer therapies based on immunomodulation.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hcc ; Chcc-cca ; Icca ; Inflammation ; Oxidative Stress; Yes-associated Protein; Causes Nonalcoholic Steatohepatitis; Oxidative Dna-damage; Hepatocellular-carcinoma; Intrahepatic Cholangiocarcinoma; Hepatitis-c; Intestinal Microbiota; Apoptotic Bodies; United-states; Kupffer Cells
ISSN (print) / ISBN
2405-8033
e-ISSN
2405-8025
Journal
Trends in cancer
Quellenangaben
Volume: 7,
Issue: 7,
Pages: 606-623
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Radiation Cytogenetics (ZYTO)