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Peripheral T-cell lymphoma with progression to a clonally related, Epstein Barr Virus plus, cytotoxic aggressive T-cell lymphoma: Evidence for secondary EBV infection of an established malignant T-cell clone.
Am. J. Surg. Pathol. 34, 1382-1387 (2010)
We report a case of primary Epstein Barr virus (EBV) negative peripheral T-cell lymphoma (PTCL) NOS in a 56-year-old female who-after an initially indolent course - simultaneously developed an aggressive, EBV+ cytotoxic large T-cell lymphoma, clonally related to the primary PTCL, and an EBV+, clonal large B-cell lymphoproliferation. The initial, EBV-negative PTCL had shown some features of angioimmunoblastic T-cell lymphoma and had responded well to steroid therapy. Two years later, rapidly fatal, progressive disease with multivisceral involvement developed. Histologically, extensive infiltrates of EBV+, CD8(+) large cells were present, in addition to areas of the initial PTCL. Extensive comparative phenotypic and molecular analyses confirmed the presence of an identical CD8(+) T-cell clone in the initial EBV-negative PTCL and the EBV+, CD8(+) large cell lymphoma at the time of aggressive transformation. These results also justified the retrospective classification of PTCL, NOS for the initial lymphoma. This case shows that secondary EBV infection of an established malignant T-cell clone can occur and may contribute to aggressive transformation of PTCL.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
PTCL; EBV; progression; cytotoxic TCL
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
0147-5185
e-ISSN
1532-0979
Quellenangaben
Volume: 34,
Issue: 9,
Pages: 1382-1387
Publisher
Lippincott Williams & Wilkins
Publishing Place
Philadelphia
Reviewing status
Peer reviewed
Institute(s)
Institute of Pathology (PATH)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-500300-001
PubMed ID
20739840
Scopus ID
77956224836
Erfassungsdatum
2010-12-31