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Hallmarks of environmental insults.
Cell 184, 1455-1468 (2021)
Publ. Version/Full Text
DOI
PMC
Environmental insults impair human health around the world. Contaminated air, water, soil, food, and occupational and household settings expose humans of all ages to a plethora of chemicals and environmental stressors. We propose eight hallmarks of environmental insults that jointly underpin the damaging impact of environmental exposures during the lifespan. Specifically, they include oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function. They provide a framework to understand why complex mixtures of environmental exposures induce severe health effects even at relatively modest concentrations.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0092-8674
e-ISSN
1097-4172
Journal
Cell
Quellenangaben
Volume: 184,
Issue: 6,
Pages: 1455-1468
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
National Institute of Environmental Health Sciences, National Institutes of Health, USA
Flemish Research Fund, Belgium
European Union's Horizon 2020 research and innovation program
Flemish Research Fund, Belgium
European Union's Horizon 2020 research and innovation program