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Open Access Green as soon as Postprint is submitted to ZB.
Potential involvement of extracellular citrate in brain tumor progression.
Curr. Mol. Med. 22, 506-513 (2021)
Brain tissue is known to have elevated citrate levels necessary to regulate ion chelation, neuron excitability, and the supply of necessary energy substrates to neurons. Importantly, citrate also acts as a central substrate in cancer metabolism. Recent studies have shown that extracellular citrate levels in the brain undergo significant changes during tumor development, and may play a dual role in tumor progression, as well as cancer cell aggressiveness. In the present article, we review available literature describing changes of citrate levels in brain tissue, blood, and cerebrospinal fluid, as well as intracellular alterations during tumor development before and after metastatic progression. Based on the available literature and our recent findings, we hypothesize that changes in extracellular citrate levels may be related to the increased consumption of this metabolite by cancer cells; interestingly, cancer-associated cells, including reactive astrocytes, might be a source of citrate. Extracellular citrate uptake mechanisms, as well as potential citrate synthesis and releasing by surrounding stroma, could provide novel targets for anti-cancer treatments of primary brain tumors and brain metastases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Brain Metastases ; Brain Tumour ; Cancer ; Citrate ; Citrate Transporter ; Metabolism
ISSN (print) / ISBN
1566-5240
e-ISSN
1875-5666
Journal
Current Molecular Medicine
Quellenangaben
Volume: 22,
Issue: 6,
Pages: 506-513
Publisher
Bentham Science Publishers
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)