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Radiation-induced DNA damage and repair in lens epithelial cells of both Ptch1(+/-) and Ercc2(+/-) mutated mice.
Radiat. Res. 197, 36-42 (2021)
Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have a contributing role in radiation-induced cataractogenesis. Recently we have reported an inverse dose-rate effect, as well as the low-dose response, of DNA damage and repair in lens epithelial cells (LECs). Here, we present further initial findings from two mutated strains (Ercc2+/- and Ptch1+/-) of mice, both reportedly susceptible to radiation-induced cataract, and their DNA damage and repair response to low-dose and low-dose-rate gamma rays. Our results support the hypothesis that the lens epithelium responds differently to radiation than other tissues, with reported radiation susceptibility to DNA damage not necessarily translating to the LECs. Genetic predisposition and strain(s) of mice have a significant role in radiation-induced cataract susceptibility.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hedgehog Signaling Pathway; Ionizing-radiation; Mouse Lens; X-ray; Induced Cataracts; Cataractogenesis; Mechanisms; Cancer; Irradiation; Deficiency
ISSN (print) / ISBN
0033-7587
e-ISSN
1938-5404
Journal
Radiation Research
Quellenangaben
Volume: 197,
Issue: 1,
Pages: 36-42
Publisher
Radiation Research Society
Publishing Place
810 E Tenth Street, Lawrence, Ks 66044 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Metabolism and Cell Death (MCD)
Grants
Euratom Research and Training Programme 2014-2018