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Omics approaches in adipose tissue and skeletal muscle addressing the role of extracellular matrix in obesity and metabolic dysfunction.
Int. J. Mol. Sci. 22:2756 (2021)
Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue (WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibro-sis, inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis. Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the most important epigenetic mechanism by which cells are able to modulate their gene expression is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach to identify DNA methylation variation associated with biological traits in humans. Likewise, Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim of this review is to explore the molecular basis of ECM in WAT and SM remodeling in obesity and the consequences of metabolic complications. For that purpose, we reviewed scientific literature including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic dysfunction and obesity.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adipose Tissue ; Epigenetic ; Extracellular Matrix ; Genetics ; Obesity ; Skeletal Muscle ; Transcriptomic
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 22,
Issue: 5,
Article Number: 2756
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
Grants
Junta de Andalucia (PAIDI, 2020)
"Ramon-Areces Foundation", Spain
doctorate contract i-PFIS: Doctorados IIS-empresa en ciencias y tecnologias de la salud
doctorate fellowship Formacion del Profesorado Universitario
"Ramon-Areces Foundation", Spain
doctorate contract i-PFIS: Doctorados IIS-empresa en ciencias y tecnologias de la salud
doctorate fellowship Formacion del Profesorado Universitario