PuSH - Publication Server of Helmholtz Zentrum München: TBL1XR1 ensures balanced neural development through NCOR complex-mediated regulation of the MAPK pathway.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Mastrototaro, G.* ; Zaghi, M.* ; Massimino, L.* ; Moneta, M.* ; Mohammadi, N.* ; Banfi, F.* ; Bellini, E.* ; Indrigo, M.* ; Fagnocchi, G.* ; Bagliani, A.* ; Taverna, S.* ; Rohm, M. ; Herzig, S. ; Sessa, A.*

TBL1XR1 ensures balanced neural development through NCOR complex-mediated regulation of the MAPK pathway.

Front. Cell Dev. Biol. 9:641410 (2021)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

TBL1XR1 gene is associated with multiple developmental disorders presenting several neurological aspects. The relative protein is involved in the modulation of important cellular pathways and master regulators of transcriptional output, including nuclear receptor repressors, Wnt signaling, and MECP2 protein. However, TBL1XR1 mutations (including complete loss of its functions) have not been experimentally studied in a neurological context, leaving a knowledge gap in the mechanisms at the basis of the diseases. Here, we show that Tbl1xr1 knock-out mice exhibit behavioral and neuronal abnormalities. Either the absence of TBL1XR1 or its point mutations interfering with stability/regulation of NCOR complex induced decreased proliferation and increased differentiation in neural progenitors. We suggest that this developmental unbalance is due to a failure in the regulation of the MAPK cascade. Taken together, our results broaden the molecular and functional aftermath of TBL1XR1 deficiency associated with human disorders.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Mapk ; Ncor ; Tbl1xr1 ; Brain Development ; Neurodevelopmental Disorders

ISSN (print) / ISBN 2296-634X

e-ISSN 2296-634X

Journal Frontiers in cell and developmental biology

Quellenangaben Volume: 9, Article Number: 641410

Publisher Frontiers

Publishing Place Lausanne

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Cancer (IDC)

Grants Helmholtz Future Topic AMPro
Italian Ministry of University and Research (PRIN2017)
Italian Ministry of Health
Telethon