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Suwandhi, L. ; Altun, I. ; Karlina, R. ; Miok, V. ; Wiedemann, T. ; Fischer, D.S. ; Walzthoeni, T. ; Lindner, C. ; Böttcher, A. ; Heinzmann, S.S. ; Israel, A. ; Khalil, A. ; Braun, A.* ; Pramme-Steinwachs, I. ; Burtscher, I. ; Schmitt-Kopplin, P. ; Heinig, M. ; Elsner, M.* ; Lickert, H. ; Theis, F.J. ; Ussar, S.

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.

Nat. Commun. 12:1588 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Adipose tissue expansion, as seen in obesity, is often metabolically detrimental causing insulin resistance and the metabolic syndrome. However, white adipose tissue expansion at early ages is essential to establish a functional metabolism. To understand the differences between adolescent and adult adipose tissue expansion, we studied the cellular composition of the stromal vascular fraction of subcutaneous adipose tissue of two and eight weeks old mice using single cell RNA sequencing. We identified a subset of adolescent preadipocytes expressing the mature white adipocyte marker Asc-1 that showed a low ability to differentiate into beige adipocytes compared to Asc-1 negative cells in vitro. Loss of Asc-1 in subcutaneous preadipocytes resulted in spontaneous differentiation of beige adipocytes in vitro and in vivo. Mechanistically, this was mediated by a function of the amino acid transporter ASC-1 specifically in proliferating preadipocytes involving the intracellular accumulation of the ASC-1 cargo D-serine.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 1588 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes and Cancer (IDC)
Institute of Computational Biology (ICB)
Institute of Diabetes and Regeneration Research (IDR)
Research Unit Analytical BioGeoChemistry (BGC)
Grants Projekt DEAL