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Harwalkar, K.* ; Ford, M.J.* ; Teng, K.* ; Yamanaka, N.* ; Yang, B.* ; Burtscher, I. ; Lickert, H. ; Yamanaka, Y.*

Anatomical and cellular heterogeneity in the mouse oviduct- its potential roles in reproduction and preimplantation development.

Biol. Reprod. 104, 1249-1261 (2021)
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The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction (UTJ) that likely play roles in reproduction. Further, we demarcated the ampulla-isthmus junction (AIJ) as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Fallopian Tube ; Luminal Epithelium ; Luminal Folds ; Oviduct ; Preimplantation Development ; Sperm Reservoir; Common Marmoset; Sperm Reservoir; Epithelium; Endoderm; Features; Isthmus; Embryo; Cells
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0006-3363
e-ISSN 1529-7268
Journal Biology of Reproduction
Quellenangaben Volume: 104, Issue: 6, Pages: 1249-1261 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502300-001
Grants Canderel graduate studentship
CCS innovation to Impact (i2I) Grant
Cancer Research Society Operation Grant
Centre for Research in Reproductuion and Development (CRRD)
Rolande & Marcel Gosselin graduate studentship
Canderel
CRRD
Fonds de recherche du Quebec - Sante (FRQS)
McGill Integrated Cancer Research Training (MICRTP) studentship
Canadian Cancer Society (CCS) Innovation Grant (Haladner Memorial Foundation)
DOI 10.1093/biolre/ioab043
WOS ID WOS:000672762100010
Scopus ID 85107902214
PubMed ID 33693543
Erfassungsdatum 2021-05-17
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