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Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish.
MicroPubl. Biol. 2021, DOI: 10.17912/micropub.biology.000369 (2021)
Sarm1 is an evolutionary conserved protein that is essential for Wallerian axon degeneration. Sarm1 has emerged as a therapeutic target to treat neuropathies derived from metabolic or chemical stress and physical injury of axons. Yet, the full repertoire of consequences of inhibiting Sarm1 remains unknown. Here we show that loss of Sarm1 in zebrafish does not affect the sensorimotor transformations that underlie rheotaxis. In addition, Sarm1 deficit accelerates the re-growth of regenerating axons. These data indicate that systemic inhibition of Sarm1 is a viable therapeutic option compatible with sustained nervous system function.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2021
HGF-reported in Year
2021
ISSN (print) / ISBN
2578-9430
e-ISSN
2578-9430
Journal
microPublication biology
Quellenangaben
Volume: 2021
Publishing Place
Pasadena, CA
Reviewing status
Peer reviewed
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500100-001
PubMed ID
33688624
Erfassungsdatum
2021-05-18