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Lutz, N.D.* ; Admard, M.* ; Genzoni, E.* ; Born, J. ; Rauss, K.*

Occipital sleep spindles predict sequence learning in a visuo-motor task.

Sleep 44:zsab056 (2021)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
STUDY OBJECTIVES: The brain appears to use internal models to successfully interact with its environment via active predictions of future events. Both internal models and the predictions derived from them are based on previous experience. However, it remains unclear how previously encoded information is maintained to support this function, especially in the visual domain. In the present study, we hypothesized that sleep consolidates newly encoded spatio-temporal regularities to improve predictions afterwards. METHODS: We tested this hypothesis using a novel sequence-learning paradigm that aimed to dissociate perceptual from motor learning. We recorded behavioral performance and high-density electroencephalography (EEG) in male human participants during initial training and during testing two days later, following an experimental night of sleep (n = 16, including high-density EEG recordings) or wakefulness (n = 17). RESULTS: Our results show sleep-dependent behavioral improvements correlated with sleep-spindle activity specifically over occipital cortices. Moreover, event-related potential (ERP) responses indicate a shift of attention away from predictable to unpredictable sequences after sleep, consistent with an enhanced automaticity in the processing of predictable sequences. CONCLUSIONS: These findings suggest a sleep-dependent improvement in the prediction of visual sequences, likely related to visual cortex reactivation during sleep spindles. Considering that controls in our experiments did not fully exclude oculomotor contributions, future studies will need to address the extent to which these effects depend on purely perceptual versus oculomotor sequence learning.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Memory ; Prediction ; Sequence Learning ; Sleep ; Visual Perception; Event-related Potentials; False Discovery Rate; Overnight Consolidation; Cognitive Performance; Memory Consolidation; Field Representation; Explicit Knowledge; Circadian-rhythms; Eye-movements; Time-course
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0161-8105
e-ISSN 1550-9109
Journal Sleep
Quellenangaben Volume: 44, Issue: 8, Pages: , Article Number: zsab056 Supplement: ,
Publisher American Academy of Sleep Medicine and the Sleep Research Society
Publishing Place Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants European Research Council (ERC)
Deutsche Forschungsgemeinschaft (SFB 1233 "Robust Vision: Inference Principles and Neural Mechanisms")
DOI 10.1093/sleep/zsab056
WOS ID WOS:000692616900015
Scopus ID 85114344789
PubMed ID 33743012
Erfassungsdatum 2021-05-21
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