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Moitinho-Silva, L.* ; Boraczynski, N.* ; Emmert, H.* ; Baurecht, H.* ; Szymczak, S.* ; Schulz, H. ; Haller, D.* ; Linseisen, J. ; Gieger, C. ; Peters, A. ; Tittmann, L.* ; Lieb, W.* ; Bang, C.* ; Franke, A.* ; Rodriguez, E.* ; Weidinger, S.*

Host traits, lifestyle and environment are associated with the human skin bacteria.

Br. J. Dermatol. 185, 573-584 (2021)
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BACKGROUND: The human skin offers diverse ecosystems for microbial symbionts. However, the factors shaping skin-microbiome interactions are still insufficiently characterized. This contrasts to the broader knowledge about the factors influencing the gut microbiota. OBJECTIVES: We aimed to investigate major patterns of associations of host traits, lifestyle, and environmental factors with skin bacteria in two German populations. METHODS: This is a cross-sectional study with 647 participants from two population-based German cohorts, PopGen (n=294) and KORA FF4 (n=353), totaling 1794 skin samples. The V1-V2 regions of the 16S rRNA gene were sequenced. Associations were tested with two bacterial levels, community (beta-diversity) and 16S rRNA gene amplicon sequence variants (ASVs). RESULTS: We validated known associations of the skin microbiota with skin microenvironment, age, body mass index (BMI) and sex. These factors were associated with beta diversity and abundance of ASVs in PopGen, which was largely replicated in KORA FF4. Most intriguingly, dietary macronutrients and total dietary energy were associated with several ASVs. ASVs were also associated with smoking, alcohol consumption, skin pH, skin type, transepidermal water loss, education, and several environmental exposures, including hours spent outdoors. Associated ASVs included members of the genera Propionibacterium, Corynebacterium, and Staphylococcus. DISCUSSION: We expand the current understanding of factors associated with the skin bacterial community. We show the association of diet with the skin bacteria. Finally, we hypothesize that the skin microenvironment and the host physiology would shape the skin bacterial community at greater extent in comparison to a single skin physiological feature, lifestyle and environmental exposition.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Human Gut Microbiome; Cutaneous Microbiome; Kora; Diversity; Psoriasis; Database
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0007-0963
e-ISSN 1365-2133
Journal British Journal of Dermatology - BJD
Quellenangaben Volume: 185, Issue: 3, Pages: 573-584 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Independent Research Group Clinical Epidemiology (KEPI)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504090-001
G-504000-009
G-502900-001
G-504091-004
G-504000-010
G-501800-401
Grants Deutsche Forschungsgemeinschaft (DFG)
Innovative Medicines Initiative 2 Joint Undertaking
European Union's Horizon 2020 research and innovation programme
EFPIA
Helmholtz Zentrum Munchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
DOI 10.1111/bjd.20072
WOS ID WOS:000651648700001
Scopus ID 85105955904
PubMed ID 33733457
Erfassungsdatum 2021-05-21
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