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Pritsch, M.* ; Radon, K.* ; Bakuli, A.* ; Le Gleut, R. ; Olbrich, L.* ; Guggenbüehl Noller, J.M.* ; Saathoff, E.* ; Castelletti, N.* ; Garí, M. ; Pütz, P. ; Schälte, Y. ; Frahnow, T. ; Wölfel, R.* ; Rothe, C.* ; Pletschette, M.* ; Metaxa, D.* ; Förster, F.* ; Thiel, V.* ; Rieß, F.* ; Diefenbach, M.N.* ; Fröschl, G.* ; Bruger, J.* ; Winter, S.* ; Frese, J.* ; Puchinger, K.* ; Brand, I.* ; Kroidl, I.* ; Hasenauer, J. ; Fuchs, C. ; Wieser, A.* ; Hoelscher, M.*

Prevalence and risk factors of infection in the representative covid-19 cohort munich.

Int. J. Environ. Res. Public Health 18:3572 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates of the magnitude of the pandemic. We therefore aimed to assess the sero-prevalence of SARS-CoV-2 in the Munich general population after the first wave of the pandemic. For this purpose, we drew a representative sample of 2994 private households and invited household members 14 years and older to complete questionnaires and to provide blood samples. SARS-CoV-2 seropositivity was defined as Roche N pan-Ig ≥ 0.4218. We adjusted the prevalence for the sampling design, sensitivity, and specificity. We investigated risk factors for SARS-CoV-2 seropositivity and geospatial transmission patterns by generalized linear mixed models and permutation tests. Seropositivity for SARS-CoV-2-specific antibodies was 1.82% (95% confidence interval (CI) 1.28–2.37%) as compared to 0.46% PCR-positive cases officially registered in Munich. Loss of the sense of smell or taste was associated with seropositivity (odds ratio (OR) 47.4; 95% CI 7.2–307.0) and infections clustered within households. By this first population-based study on SARS-CoV-2 prevalence in a large German municipality not affected by a superspreading event, we could show that at least one in four cases in private households was reported and known to the health authorities. These results will help authorities to estimate the true burden of disease in the population and to take evidence-based decisions on public health measures.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Covid-19 ; Infection Fatality Ratio ; Population-based Cohort Study ; Sars-cov-2 ; Seroprevalence ; Underreporting
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1661-7827
e-ISSN 1660-4601
Journal International Journal of Environmental Research and Public Health
Quellenangaben Volume: 18, Issue: 7, Pages: , Article Number: 3572 Supplement: ,
Publisher MDPI
Publishing Place Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503800-001
G-553800-001
Grants German Ministry for Education and Research
University of Bielefeld
University of Bonn
Helmholtz Centre Munich
University Hospital, LMU Munich
Bavarian State Ministry of Science and the Arts
DOI 10.3390/ijerph18073572
WOS ID WOS:000638532400001
Scopus ID 85103246421
PubMed ID 33808249
Erfassungsdatum 2021-05-05
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