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Weber, M. ; Padmanabhan Nair, V. ; Bauer, T. ; Sprinzl, M.F.* ; Protzer, U. ; Vincendeau, M.

Increased HERV-K(HML-2) transcript levels correlate with clinical parameters of liver damage in hepatitis C patients.

Cells 10:774 (2021)

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Chronic hepatitis C virus (HCV) infection is closely associated with a plethora of diseases, including cancers and autoimmune disorders. However, the distinct triggers and cellular networks leading to such HCV-derived diseases are poorly understood. Around 8% of the human genome consists of human endogenous retroviruses. They are usually silenced but can be reactivated by environmental conditions, including viral infections. Our current understanding indicates that the activation of one specific family-namely, HERV-K(HML-2)-is linked to distinct pathologies, including cancer and autoimmunity. In this study, we analyzed the transcription levels of HERV-K(HML-2) in 42 HCV-infected patients receiving direct-acting antiviral therapies. Samples from the start of treatment until 12 weeks post-treatment were investigated. Our results show increased HERV-K(HML-2) transcript levels in patients with HCV-derived liver cirrhosis throughout the observation period. Several clinical parameters specifying poor liver function are positively correlated with HERV-K(HML-2) expression. Of note, patients without a sustained viral clearance showed a drastic increase in HERV-K(HML-2) transcript levels. Together, our data suggest that increased HERV-K(HML-2) expression is correlated with reduced liver function as well as therapy success in HCV-infected patients.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Albumin ; Direct-acting Antivirals ; Hepatitis C Virus ; Human Endogenous Retroviruses ; Liver Cirrhosis ; Viral Clearance

ISSN (print) / ISBN 2073-4409

e-ISSN 2073-4409

Journal Cells

Quellenangaben Volume: 10, Issue: 4, Article Number: 774

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Institute(s) Institute of Virology (VIRO)