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Deng, Y.* ; Chatterjee, B.* ; Zens, K.* ; Zdimerova, H.* ; Müller, A.* ; Schuhmachers, P.* ; Ligeon, L.A.* ; Bongiovanni, A.* ; Capaul, R.* ; Zbinden, A.* ; Holler, A.* ; Stauss, H.J.* ; Hammerschmidt, W. ; Münz, C.*

CD27 is required for protective lytic EBV antigen specific CD8+ T cell expansion.

Blood 137, 3225-3236 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Primary immunodeficiencies in the co-stimulatory molecule CD27 and its ligand CD70 predispose for pathologies of uncontrolled Epstein Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27 positive cells and antibody blocking of CD27 interaction with CD70 causes uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T cell expansion and composition is unaltered after antibody blocking of CD27, only some EBV specific CD8+ T cell responses, exemplified by early lytic EBV antigen BMLF1 specific CD8+ T cells are inhibited in their proliferation and killing of EBV transformed B cells. This suggests that CD27 is not required for all CD8+ T cell expansions and cytotoxicity, but for a subset of CD8+ T cell responses that protect us from EBV infection.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Epstein-barr-virus; Linked Lymphoproliferative Disease; Natural-killer-cells; Combined Immunodeficiency; Cultured Lymphoblasts; Expression; Differentiation; Lymphoma; Humans; Family
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 137, Issue: 23, Pages: 3225-3236 Article Number: , Supplement: ,
Publisher American Society of Hematology
Publishing Place 2021 L St Nw, Suite 900, Washington, Dc 20036 Usa
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-501500-001
DOI 10.1182/blood.2020009482
WOS ID WOS:000667997800007
PubMed ID 33827115
Erfassungsdatum 2021-05-28
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