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Multifunctional magneto-plasmonic fe3o4/au nanocomposites: Approaching magnetophoretically-enhanced photothermal therapy.
Nanomaterials 11:1113 (2021)
Magneto-plasmonic nanocomposites can possess properties inherent to both individual components (iron oxide and gold nanoparticles) and are reported to demonstrate high potential in targeted drug delivery and therapy. Herein, we report on Fe O /Au magneto-plasmonic nanocomposites (MPNC) synthesized with the use of amino acid tryptophan via chemical and photochemical reduction of Au ions in the presence of nanosized magnetite. The magnetic field (MF) induced aggregation was accompanied by an increase in the absorption in the near-infrared (NIR) spectral region, which was demonstrated to provide an enhanced photothermal (PT) effect under NIR laser irradiation (at 808 nm). A possibility for therapeutic application of the MPNC was illustrated using cancer cells in vitro. Cultured HeLa cells were treated by MPNC in the presence of MF and without it, following laser irradiation and imaging using confocal laser scanning microscopy. After scanning laser irradiation of the MPNC/MF treated cells, a formation and rise of photothermally-induced microbubbles on the cell surfaces was observed, leading to a damage of the cell membrane and cell destruction. We conclude that the synthesized magneto-plasmonic Fe O /Au nanosystems exhibit magnetic field-induced reversible aggregation accompanied by an increase in NIR absorption, allowing for an opportunity to magnetophoretically control and locally enhance a NIR light-induced thermal effect, which holds high promise for the application in photothermal therapy. 3 4 3 4
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Fe O And Au Nanocomposites 3 4 ; Hela Cells ; Magneto-plasmonic ; Magnetophoretic Control ; Microbubbles ; Near Infrared ; Photothermal Therapy; Gold Nanorods; Nanoparticles; Aggregation; Nanoclusters; Nanostars; Delivery
ISSN (print) / ISBN
2079-4991
e-ISSN
2079-4991
Journal
Nanomaterials
Quellenangaben
Volume: 11,
Issue: 5,
Article Number: 1113
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
Visiting Researcher Program of TU Chemnitz
National Natural Science Foundation of China
National Academy of Sciences of Ukraine
National Natural Science Foundation of China
National Academy of Sciences of Ukraine