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Stoleriu, M.-G. ; Gerckens, M. ; Obereisenbuchner, F.* ; Zaimova, I.* ; Hetrodt, J.* ; Mavi, S.C.* ; Schmidt, F.* ; Schoenlebe, A.A.* ; Heinig-Menhard, K.* ; Koch, I. ; Jörres, R.A.* ; Spiro, J.* ; Nowak, L.* ; Hatz, R. ; Behr, J. ; Gesierich, W. ; Heiß-Neumann, M.* ; Dinkel, J.

Automated quantitative thin slice volumetric low dose CT analysis predicts disease severity in COVID-19 patients.

Clin. Imaging 79, 96-101 (2021)
DOI PMC
Purpose: This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis, clinical chemistry and lung function testing. Methods: Seventy-four COVID-19 patients admitted between March 16th and June 3rd 2020 to the Asklepios Lung Clinic Munich-Gauting, Germany, were included in the study. Patients were categorized in a non-severe group including patients hospitalized on general wards only and in a severe group including patients requiring intensive care treatment. Fully automated quantification of CT scans was performed via IMBIO CT Lung Texture analysis™ software. Predictive biomarkers were assessed with receiver-operator-curve and likelihood analysis. Results: Fifty-five patients (44% female) presented with non-severe COVID-19 and 19 patients (32% female) with severe disease. Five fatalities were reported in the severe group. Accurate automated CT analysis was possible with 61 CTs (82%). Disease severity was linked to lower residual normal lung (72.5% vs 87%, p = 0.003), increased ground glass opacities (GGO) (8% vs 5%, p = 0.031) and increased reticular pattern (8% vs 2%, p = 0.025). Disease severity was associated with advanced age (76 vs 59 years, p = 0.001) and elevated serum C-reactive protein (CRP, 92.2 vs 36.3 mg/L, p < 0.001), lactate dehydrogenase (LDH, 485 vs 268 IU/L, p < 0.001) and oxygen supplementation (p < 0.001) upon admission. Predictive risk factors for the development of severe COVID-19 were oxygen supplementation, LDH >313 IU/L, CRP >71 mg/L, <70% normal lung texture, >12.5% GGO and >4.5% reticular pattern. Conclusion: Automated low dose CT analysis upon admission might be a useful tool to predict COVID-19 severity in patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Covid-19 Pneumonia ; Ct Analysis ; Low Dose Volumetric Ct
ISSN (print) / ISBN 0899-7071
e-ISSN 1873-4499
Journal Clinical imaging
Quellenangaben Volume: 79, Issue: , Pages: 96-101 Article Number: , Supplement: ,
Publisher Elsevier
Institute(s) Institute of Lung Health and Immunity (LHI)