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Appelman, M.D.* ; Wettengel, J.M. ; Protzer, U. ; Oude Elferink, R.P.J.* ; van de Graaf, S.F.J.*

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1866:158960 (2021)

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Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Asbt ; Bsep ; Cholestasis ; Hbv ; Hdv; Taurocholate Cotransporting Polypeptide; B-virus Infection; Organic Anion Transporters; Na+/taurocholate Cotransport; Dependent Translocation; Nuclear Receptor; Rat Ntcp; Expression; Inhibition; Mouse

ISSN (print) / ISBN 1388-1981

Journal Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids

Quellenangaben Volume: 1866, Issue: 8, Article Number: 158960

Publisher Elsevier

Publishing Place Amsterdam

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)

Grants Amsterdam University Medical Centers (AUMC)
Dioraphte Foundation
Dutch Cancer Foundation (KWF)
German Research Foundation (DFG)
Amsterdam University Medical Centers (AGEM innovation grant)