PuSH - Publication Server of Helmholtz Zentrum München: Is LRP2 involved in leptin transport over the blood-brain barrier and development of obesity?

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Sandin, E.S.* ; Folberth, J.* ; Müller-Fielitz, H.* ; Pietrzik, C.U.* ; Herold, E.* ; Willnow, T.E.* ; Pfluger, P.T. ; Nogueiras, R.* ; Prévot, V.* ; Schwaninger, M.*

Is LRP2 involved in leptin transport over the blood-brain barrier and development of obesity?

Int. J. Mol. Sci. 22:4998 (2021)

Postprint

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

The mechanisms underlying the transport of leptin into the brain are still largely unclear. While the leptin receptor has been implicated in the transport process, recent evidence has suggested an additional role of LRP2 (megalin). To evaluate the function of LRP2 for leptin transport across the blood-brain barrier (BBB), we developed a novel leptin-luciferase fusion protein (pLG), which stimulated leptin signaling and was transported in an in vitro BBB model based on porcine endothelial cells. The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of LRP2 in brain endothelial cells and epithelial cells of the choroid plexus did not influence bodyweight, body composition, food intake, or energy expenditure of mice. These findings suggest that LRP2 at the BBB is not involved in the transport of leptin into the brain, nor in the development of obesity as has previously been described.

Impact Factor

Scopus SNIP

Altmetric

5.923

1.441