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Aboelnour, E. ; Bonev, B.

Decoding the organization, dynamics, and function of the 4D genome.

Dev. Cell 56, 1562-1573 (2021)
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Understanding how complex cell-fate decisions emerge at the molecular level is a key challenge in developmental biology. Despite remarkable progress in decoding the contribution of the linear epigenome, how spatial genome architecture functionally informs changes in gene expression remains unclear. In this review, we discuss recent insights in elucidating the molecular landscape of genome folding, emphasizing the multilayered nature of the 3D genome, its importance for gene regulation, and its spatiotemporal dynamics. Finally, we discuss how these new concepts and emergent technologies will enable us to address some of the outstanding questions in development and disease.
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Publication type Article: Journal article
Document type Review
Keywords 4d Genome ; Cell Identity ; Gene Regulation ; Nuclear Architecture; 3d Chromatin Architecture; Chromosome Conformation; Dna Methylation; Gene-expression; Domains; Landscape; Topology; Reveal; Reorganization; Principles
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Journal Developmental Cell
Quellenangaben Volume: 56, Issue: 11, Pages: 1562-1573 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Pioneer Campus
PSP Element(s) G-510004-001
Grants Helmholtz-Gemeinschaft
DFG
Helmholtz Pioneer Campus
DOI 10.1016/j.devcel.2021.04.023
WOS ID WOS:000659463100004
Scopus ID 85107123354
PubMed ID 33984271
Erfassungsdatum 2021-06-18
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