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Decoding the organization, dynamics, and function of the 4D genome.
Dev. Cell 56, 1562-1573 (2021)
Publ. Version/Full Text
DOI
PMC
Understanding how complex cell-fate decisions emerge at the molecular level is a key challenge in developmental biology. Despite remarkable progress in decoding the contribution of the linear epigenome, how spatial genome architecture functionally informs changes in gene expression remains unclear. In this review, we discuss recent insights in elucidating the molecular landscape of genome folding, emphasizing the multilayered nature of the 3D genome, its importance for gene regulation, and its spatiotemporal dynamics. Finally, we discuss how these new concepts and emergent technologies will enable us to address some of the outstanding questions in development and disease.
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Publication type
Article: Journal article
Document type
Review
Keywords
4d Genome ; Cell Identity ; Gene Regulation ; Nuclear Architecture; 3d Chromatin Architecture; Chromosome Conformation; Dna Methylation; Gene-expression; Domains; Landscape; Topology; Reveal; Reorganization; Principles
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Journal
Developmental Cell
Quellenangaben
Volume: 56,
Issue: 11,
Pages: 1562-1573
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)
Grants
Helmholtz-Gemeinschaft
DFG
Helmholtz Pioneer Campus
DFG
Helmholtz Pioneer Campus