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Buchmann, B.* ; Engelbrecht, L.K. ; Fernandez, P.* ; Hutterer, F.P.* ; Raich, M.K.* ; Scheel, C. ; Bausch, A.R.*

Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids.

Nat. Commun. 12:2759 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Epithelial branch elongation is a central developmental process during branching morphogenesis in diverse organs. This fundamental growth process into large arborized epithelial networks is accompanied by structural reorganization of the surrounding extracellular matrix (ECM), well beyond its mechanical linear response regime. Here, we report that epithelial ductal elongation within human mammary organoid branches relies on the non-linear and plastic mechanical response of the surrounding collagen. Specifically, we demonstrate that collective back-and-forth motion of cells within the branches generates tension that is strong enough to induce a plastic reorganization of the surrounding collagen network which results in the formation of mechanically stable collagen cages. Such matrix encasing in turn directs further tension generation, branch outgrowth and plastic deformation of the matrix. The identified mechanical tension equilibrium sets a framework to understand how mechanical cues can direct ductal branch elongation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Extracellular-matrix; Cell; Migration; Dynamics; Morphogenesis; Expression; Tube; Intercalation; Deformation; Integrin
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 2759 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500890-001
Grants Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme
DOI 10.1038/s41467-021-22988-2
WOS ID WOS:000668325300002
Scopus ID 85105776735
PubMed ID 33980857
Erfassungsdatum 2021-06-18
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