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Huang, Y. ; Omar, M. ; Tian, W. ; López-Schier, H. ; Westmeyer, G.G. ; Chmyrov, A. ; Sergiadis, G. ; Ntziachristos, V.

Noninvasive visualization of electrical conductivity in tissues at the micrometer scale.

Sci. Adv. 7:eabd1505 (2021)
Publ. Version/Full Text Research data DOI PMC
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Despite its importance in regulating cellular or tissue function, electrical conductivity can only be visualized in tissue indirectly as voltage potentials using fluorescent techniques, or directly with radio waves. These either requires invasive procedures like genetic modification or suffers from limited resolution. Here, we introduce radio-frequency thermoacoustic mesoscopy (RThAM) for the noninvasive imaging of conductivity by exploiting the direct absorption of near-field ultrashort radio-frequency pulses to stimulate the emission of broadband ultrasound waves. Detection of ultrasound rather than radio waves enables micrometer-scale resolutions, over several millimeters of tissue depth. We confirm an imaging resolution of <30 μm in phantoms and demonstrate microscopic imaging of conductivity correlating to physical structures in 1- and 512-cell zebrafish embryos, as well as larvae. These results support RThAM as a promising method for high-resolution, label-free assessment of conductivity in tissues.
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Publication type Article: Journal article
Document type Scientific Article
Keywords In-vivo; Dielectric Spectrum; Tomography; Membrane; Contrast; Signals; Sensors; Ct
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Journal Science Advances
Quellenangaben Volume: 7, Issue: 20, Pages: , Article Number: eabd1505 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington, DC [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Research Unit Sensory Biology and Organogenesis (SBO)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30204 - Cell Programming and Repair
Research field(s) Enabling and Novel Technologies
Stem Cell and Neuroscience
PSP Element(s) G-505500-001
G-500100-001
G-505592-001
Grants CSC Fellowship
Deutsche Forschungsgemeinschaft (DFG), Germany
DOI 10.1126/sciadv.abd1505
WOS ID WOS:000652258100001
Scopus ID 85105809235
PubMed ID 33980478
Erfassungsdatum 2021-06-18
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