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Dem Anfang auf der Spur — die Suche nach DNA-Replikationsursprüngen.
On the trail of the beginning - The search for DNA replication origins.
BioSpektrum 27, 246-249 (2021)
Timely and accurate duplication of DNA prior to cell division is a prerequisite for propagation of the genetic material to both daughter cells. DNA synthesis initiates at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, a uniform method that identifies origins of replication in a comprehensive manner is still missing. Here, we present currently available and discuss new approaches to map replication origins in mammalian genomes.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 27,
Issue: 3,
Pages: 246-249
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)