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Regenerative medicine and the hope for a cure.
Clin. Chest Med. 42, 365-373 (2021)
Current therapeutic strategies have succeeded in slowing down the progression of idiopathic pulmonary fibrosis (IPF). Emerging evidence highlights IPF as a disease of aging and impaired regeneration. Novel antiaging and regenerative medicine approaches hold promise to be able to reverse disease and might present hope for a cure. Research focusing on a deeper understanding of lung stem cell populations and how these are regulated and altered in fibrotic disease continues to drive the field, and accompanied by earlier diagnosis, the adaptation of clinically relevant models and readouts for regeneration of diseased lung, ultimately paves the way for translation into clinics.
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Publication type
Article: Journal article
Document type
Review
Keywords
Aging ; Cellular Senescence ; Developmental Pathways ; Ild ; Ipf ; Regeneration ; Translation; Idiopathic Pulmonary-fibrosis; Cellular Senescence; Lung Development; Stem-cells; Alveolar Progenitor; Aging Lung; Wnt; Mechanisms; Repair; Tgf
ISSN (print) / ISBN
0272-5231
e-ISSN
1557-8216
Journal
Clinics in chest medicine
Quellenangaben
Volume: 42,
Issue: 2,
Pages: 365-373
Publisher
Elsevier
Publishing Place
1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)