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Lehmann, M. ; Königshoff, M.

Regenerative medicine and the hope for a cure.

Clin. Chest Med. 42, 365-373 (2021)
Postprint DOI PMC
Current therapeutic strategies have succeeded in slowing down the progression of idiopathic pulmonary fibrosis (IPF). Emerging evidence highlights IPF as a disease of aging and impaired regeneration. Novel antiaging and regenerative medicine approaches hold promise to be able to reverse disease and might present hope for a cure. Research focusing on a deeper understanding of lung stem cell populations and how these are regulated and altered in fibrotic disease continues to drive the field, and accompanied by earlier diagnosis, the adaptation of clinically relevant models and readouts for regeneration of diseased lung, ultimately paves the way for translation into clinics.
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Publication type Article: Journal article
Document type Review
Keywords Aging ; Cellular Senescence ; Developmental Pathways ; Ild ; Ipf ; Regeneration ; Translation; Idiopathic Pulmonary-fibrosis; Cellular Senescence; Lung Development; Stem-cells; Alveolar Progenitor; Aging Lung; Wnt; Mechanisms; Repair; Tgf
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0272-5231
e-ISSN 1557-8216
Journal Clinics in chest medicine
Quellenangaben Volume: 42, Issue: 2, Pages: 365-373 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Lung Research
PSP Element(s) G-503100-001
G-501800-311
DOI 10.1016/j.ccm.2021.03.012
WOS ID WOS:000653200800014
PubMed ID 34024411
Erfassungsdatum 2021-06-28
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