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von Streitberg, A.* ; Jäkel, S.* ; Eugenin von Bernhardi, J.* ; Straube, C.* ; Buggenthin, F. ; Marr, C. ; Dimou, L.*

NG2-glia transiently overcome their homeostatic network and contribute to wound closure after brain injury.

Front. Cell Dev. Biol. 9:662056 (2021)

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In the adult brain, NG2-glia represent a cell population that responds to injury. To further investigate if, how and why NG2-glia are recruited to the injury site, we analyzed in detail the long-term reaction of NG2-glia after a lesion by time-lapse two-photon in vivo microscopy. Live imaging over several weeks of GFP-labeled NG2-glia in the stab wounded cerebral cortex revealed their fast and heterogeneous reaction, including proliferation, migration, polarization, hypertrophy, or a mixed response, while a small subset of cells remained unresponsive. At the peak of the reaction, 2-4 days after the injury, NG2-glia accumulated around and within the lesion core, overcoming the homeostatic control of their density, which normalized back to physiological conditions only 4 weeks after the insult. Genetic ablation of proliferating NG2-glia demonstrated that this accumulation contributed beneficially to wound closure. Thus, NG2-glia show a fast response to traumatic brain injury (TBI) and participate in tissue repair.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords In Vivo Two-photon Imaging ; Migration ; Polarization ; Proliferation ; Stab Wound Injury; Oligodendrocyte Precursor Cells; Motor Cortex; Axon Growth; Ng2 Cells; Progenitors; Proliferation; Generation; Migration; Responses; Demyelination

ISSN (print) / ISBN 2296-634X

e-ISSN 2296-634X

Journal Frontiers in cell and developmental biology

Quellenangaben Volume: 9, Article Number: 662056

Publisher Frontiers

Publishing Place Lausanne

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Computational Biology (ICB)

Grants BMBF-Federal Ministry of Education and Research, Germany (ERA-NET "Network of European Funding for Neuroscience Research," NEURON)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)