PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Chan, C.C.* ; Pfluger, P.T. ; Trompette, A.* ; Stankiewicz, T.E.* ; Allen, J.L.* ; Moreno-Fernandez, M.E.* ; Damen, M.S.M.A.* ; Oates, J.R.* ; Alarcon, P.C.* ; Doll, J.R.* ; Flick, M.J.* ; Flick, L.M.* ; Sanchez-Gurmaches, J.* ; Mukherjee, R.* ; Karns, R.* ; Helmrath, M.* ; Inge, T.H.* ; Weisberg, S.P.* ; Pamp, S.J.* ; Relman, D.A.* ; Seeley, R.J.* ; Karp, C.L. ; Divanovic, S.*

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.

Nat. Commun. 12:2911 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating factor (BAFF). Here we show that overexpression of BAFF in multiple mouse models associates with protection from weight gain, approximating a log-linear dose response relation to BAFF concentrations. Gene expression analysis of BAFF-stimulated subcutaneous white adipocytes unveils upregulation of lipid metabolism pathways, with BAFF inducing white adipose tissue (WAT) lipolysis. Brown adipose tissue (BAT) from BAFF-overexpressing mice exhibits increased Ucp1 expression and BAFF promotes brown adipocyte respiration and in vivo energy expenditure. A proliferation-inducing ligand (APRIL), a BAFF homolog, similarly modulates WAT and BAT lipid handling. Genetic deletion of both BAFF and APRIL augments diet-induced obesity. Lastly, BAFF/APRIL effects are conserved in human adipocytes and higher BAFF/APRIL levels correlate with greater BMI decrease after bariatric surgery. Together, the BAFF/APRIL axis is a multifaceted immune regulator of weight gain and adipose tissue function.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
14.919
3.055
2
8
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Tumor-necrosis-factor; Fatty Liver-disease; Signal-related Kinase; Factor-alpha; Insulin-resistance; Induced Obesity; Brown Fat; Metabolic Syndrome; Hepatic Steatosis; April Expression
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 2911 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502294-001
G-502200-001
Grants NIDDK NIH HHS
NIGMS NIH HHS
NIAID NIH HHS
DOI 10.1038/s41467-021-23084-1
WOS ID WOS:000655481800013
Scopus ID 85106181376
PubMed ID 34006859
Erfassungsdatum 2021-06-28
[➜Report correction]