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Ageeva-Kieferle, A. ; Georgii, E. ; Winkler, B. ; Ghirardo, A. ; Albert, A. ; Hüther, P.* ; Mengel, A. ; Becker, C.* ; Schnitzler, J.-P. ; Durner, J. ; Lindermayr, C.

Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression.

Plant Physiol. 187, 336-360 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
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Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO correspond to changes in global histone acetylation (H3, H3K9 and H3K9/K14) in Arabidopsis (Arabidopsis thaliana) wild-type leaves, and that this relationship depends on S-nitrosoglutathione reductase (GSNOR) and histone deacetylase 6 (HDA6). The activity of HDA6 was sensitive to NO, demonstrating that NO participates in regulation of histone acetylation. ChIP-seq and RNA-seq analyses revealed that NO participates in the metabolic switch from growth and development to stress response. This coordinating function of NO might be particularly important in plant ability to adapt to a changing environment, and is therefore a promising foundation for mitigating the negative effects of climate change on plant productivity.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nitric Oxide ; S-nitrosoglutathione Reductase ; S-nitrosothiols ; Development ; Epigenetics ; Growth ; Histone Acetylation ; Histone Deacetylase 6 ; Stress Response; S-nitrosylated Proteins; Arabidopsis-thaliana; Nitrosoglutathione Reductase; Proteomic Analysis; Oxidative Stress; Light Regulation; Abscisic-acid; Jasmonic Acid; Plant-growth; Synthase Nos
ISSN (print) / ISBN 0032-0889
e-ISSN 1532-2548
Journal Plant Physiology
Quellenangaben Volume: 187, Issue: 1, Pages: 336-360 Article Number: , Supplement: ,
Publisher American Society of Plant Biologists (ASPB)
Publishing Place Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biochemical Plant Pathology (BIOP)
Research Unit Environmental Simulation (BIOP-EUS)
Grants Bundesministerium fur Bildung und Forschung (BMBF)