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Nerpin, E.* ; Ferreira, D.S.* ; Weyler, J.* ; Schlunnsen, V.* ; Jõgi, R.* ; Raherison Semjen, C.* ; Gislasson, T.* ; Demoly, P.* ; Heinrich, J. ; Nowak, D.* ; Corsico, A.* ; Accordini, S.* ; Marcon, A.* ; Squillacioti, G.* ; Olivieri, M.* ; Nielsen, R.* ; Johannessen, A.* ; Gómez Real, F.* ; Garcia-Aymerich, J.* ; Urrutia, I.* ; Pereira-Vega, A.* ; Gullón, J.A.* ; Olin, A.C.* ; Forsberg, B.* ; Emilsson, Ö.I.* ; Pin, I.* ; Jarvis, D.* ; Janson, C.* ; Malinovschi, A.*

Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.

World Allergy Organiz. J. 14:100544 (2021)
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Background: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. Objectives: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Methods: Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. Results: Among asthmatic subjects, higher percentage declines of FEV and FEV /FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses. Percentage increase in FEV after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV and FeNO levels in non-smokers and women, regardless of asthma status. Conclusions: We found a relationship between elevated FeNO and larger FEV decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Bronchodilatation ; Epidemiology ; Feno ; Lung Function; Air-flow Limitation; Inhaled Corticosteroids; Reference Values; Asthma; Health; Prevalence; Adults; Atopy; Contributes; Obstruction
Language english
Publication Year 2021
HGF-reported in Year 2021
e-ISSN 1939-4551
Journal World Allergy Organization Journal
Quellenangaben Volume: 14, Issue: 5, Pages: , Article Number: 100544 Supplement: ,
Publisher BioMed Central
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
Grants Generalitat de Catalunya
Spanish Ministry of Science and Innovation
Medical Research Council
DOI 10.1016/j.waojou.2021.100544
WOS ID WOS:000658539200005
Scopus ID 85106214518
PubMed ID 34093956
Erfassungsdatum 2021-06-29
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