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Alboushi, L.* ; Hackett, A.P.* ; Naeli, P.* ; Bakhti, M. ; Jafarnejad, S.M.*

Multifaceted control of mRNA translation machinery in cancer.

Cell. Signal. 84:110037 (2021)
Postprint DOI PMC
Open Access Green
The mRNA translation machinery is tightly regulated through several, at times overlapping, mechanisms that modulate its efficiency and accuracy. Due to their fast rate of growth and metabolism, cancer cells require an excessive amount of mRNA translation and protein synthesis. However, unfavorable conditions, such as hypoxia, amino acid starvation, and oxidative stress, which are abundant in cancer, as well as many anti-cancer treatments inhibit mRNA translation. Cancer cells adapt to the various internal and environmental stresses by employing specialised transcript-specific translation to survive and gain a proliferative advantage. We will highlight the major signaling pathways and mechanisms of translation that regulate the global or mRNA-specific translation in response to the intra- or extra-cellular signals and stresses that are key components in the process of tumourigenesis.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cancer ; Elongation ; Initiation ; Mrna Translation ; Protein Synthesis ; Ribosome Recycling ; Signaling Pathway ; Stress ; Termination ; Translation Machinery ; Tumourigenesis; Internal-ribosome-entry; Initiation-factor 4e; Cap-binding Protein; Elongation-factor 2; La-related Protein-1; P70 S6 Kinase; Factor 4e-binding Protein-1; Integrated Stress-response; To-mesenchymal Transition; Ires-mediated Translation
ISSN (print) / ISBN 0898-6568
e-ISSN 0898-6568
Journal Cellular Signalling
Quellenangaben Volume: 84, Issue: , Pages: , Article Number: 110037 Supplement: ,
Publisher Elsevier
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
Grants New Frontiers in Research Fund-Exploration (Canada)
Medical Research Council, United Kingdom (MRC)