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Fibroblasts as confederates of the immune system.
Immunol. Rev. 302, 147-162 (2021)
Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in the mammalian body. This cellular variety impacts the spectrum of responses elicited by the immune system. Fibroblast influence on the immune system keeps evolving our perspective on fibroblast roles and functions beyond just a passive structural part of organs. This review discusses the foundations of fibroblastic stromal-immune crosstalk, under the scope of stromal heterogeneity as a basis for tissue-specific tutoring of the immune system. Focusing on the skin as a relevant immunological organ, we detail the complex interactions between distinct fibroblast populations and immune cells that occur during homeostasis, injury repair, scarring, and disease. We further review the relevance of fibroblastic stromal cell heterogeneity and how this heterogeneity is central to regulate the immune system from its inception during embryonic development into adulthood.
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Publication type
Article: Journal article
Document type
Review
Keywords
Development ; Extracellular Matrix ; Fibroblast ; Immunological Niche ; Scarring ; Skin ; Stromal Cell ; Wound Healing; Hematopoietic Stem-cells; Intercellular-adhesion Molecule-1; Extracellular-matrix Protein; Epidermal Langerhans Cells; Bone-marrow Microenvironment; Hepatic Stellate Cells; Regulatory T-cells; Stromal Cells; Fetal Liver; Single-cell
ISSN (print) / ISBN
0105-2896
e-ISSN
1600-065X
Journal
Immunological Reviews
Quellenangaben
Volume: 302,
Issue: 1,
Pages: 147-162
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Regenerative Biology and Medicine (IRBM)
Institute of Lung Health and Immunity (LHI)
Institute of Lung Health and Immunity (LHI)
Grants
Else-Kroner-Fresenius-Stiftung
European Research Council Consolidator Grant
Deutsche Forschungsgemeinschaft
Human Frontier Science Program Career Development Award
Fritz-Thyssen-Stiftung
European Research Council Consolidator Grant
Deutsche Forschungsgemeinschaft
Human Frontier Science Program Career Development Award
Fritz-Thyssen-Stiftung