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Mühlbacher, T. ; Amann, K.* ; Mahling, M. ; Nadalin, S.* ; Heyne, N. ; Guthoff, M.

Successful long-term management of recurrent focalsegmental glomerulosclerosis after kidneytransplantation with costimulation blockade.

Clin. Kidney J. 14, 1691-1693 (2021)
Publ. Version/Full Text DOI PMC
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Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19-year-old patient with recurrent primary FSGS early after living donor kidney transplantation. Plasmapheresis and rituximab did not induce remission. Repetitive abatacept administration was able to achieve partial remission. Maintenance immunosuppression was subsequently switched to a belatacept-based calcineurin inhibitor-free immunosuppression, resulting in sustained complete remission with excellent allograft function throughout a follow-up of >56 months.
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Publication type Article: Journal article
Document type Review
Keywords B7-1 ; Belatacept ; Focal Segmental Glomerulosclerosis ; Kidney Transplantation ; Nephrotic Syndrome ; Recurrence; B7-1
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2048-8505
e-ISSN 2048-8513
Journal Clinical Kidney Journal
Quellenangaben Volume: 14, Issue: 6, Pages: 1691-1693 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants Open Access Publishing Fund of University of Tubingen
Deutsche Forschungsgemeinschaft
DOI 10.1093/ckj/sfaa267
WOS ID WOS:000697706000024
PubMed ID 34084465
Erfassungsdatum 2021-07-01
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