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Successful long-term management of recurrent focalsegmental glomerulosclerosis after kidneytransplantation with costimulation blockade.
Clin. Kidney J. 14, 1691-1693 (2021)
Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19-year-old patient with recurrent primary FSGS early after living donor kidney transplantation. Plasmapheresis and rituximab did not induce remission. Repetitive abatacept administration was able to achieve partial remission. Maintenance immunosuppression was subsequently switched to a belatacept-based calcineurin inhibitor-free immunosuppression, resulting in sustained complete remission with excellent allograft function throughout a follow-up of >56 months.
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Publication type
Article: Journal article
Document type
Review
Keywords
B7-1 ; Belatacept ; Focal Segmental Glomerulosclerosis ; Kidney Transplantation ; Nephrotic Syndrome ; Recurrence; B7-1
ISSN (print) / ISBN
2048-8505
e-ISSN
2048-8513
Journal
Clinical Kidney Journal
Quellenangaben
Volume: 14,
Issue: 6,
Pages: 1691-1693
Publisher
Oxford University Press
Publishing Place
Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Grants
Open Access Publishing Fund of University of Tubingen
Deutsche Forschungsgemeinschaft
Deutsche Forschungsgemeinschaft