PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Lesch, S.* ; Blumenberg, V.* ; Stoiber, S.* ; Gottschlich, A.* ; Ogonek, J.* ; Cadilha, B.L.* ; Dantes, Z.* ; Rataj, F.* ; Dorman, K.* ; Lutz, J.* ; Karches, C.H.* ; Heise, C.* ; Kurzay, M.* ; Larimer, B.M.* ; Grassmann, S.* ; Rapp, M.* ; Nottebrock, A.* ; Krüger, S.* ; Tokarew, N.* ; Metzger, P.* ; Hoerth, C.* ; Benmebarek, M.R.* ; Dhoqina, D.* ; Grünmeier, R.* ; Seifert, M.* ; Oener, A.* ; Umut, Ö.* ; Joaquina, S.* ; Vimeux, L.* ; Tran, T.* ; Hank, T.* ; Baba, T.* ; Huynh, D.* ; Megens, R.T.A.* ; Janssen, K.P.* ; Jastroch, M. ; Lamp, D. ; Ruehland, S.* ; Di Pilato, M.* ; Pruessmann, J.N.* ; Thomas, M. ; Marr, C. ; Ormanns, S.* ; Reischer, A.* ; Hristov, M.* ; Tartour, E.* ; Donnadieu, E.* ; Rothenfußer, S. ; Duewell, P.* ; König, L.M.* ; Schnurr, M.* ; Subklewe, M.* ; Liss, A.S.* ; Halama, N.* ; Reichert, M.* ; Mempel, T.R.* ; Endres, S. ; Kobold, S.

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nat. Bio. Eng. 5, 1246-1260 (2021)
Postprint DOI PMC
Open Access Green
The efficacy of adoptive cell therapy for solid tumours is hampered by the poor accumulation of the transferred T cells in tumour tissue. Here, we show that forced expression of C-X-C chemokine receptor type 6 (whose ligand is highly expressed by human and murine pancreatic cancer cells and tumour-infiltrating immune cells) in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer. In mice with subcutaneous pancreatic tumours treated with T cells with either a transgenic T-cell receptor or a murine chimeric antigen receptor targeting the tumour-associated antigen epithelial cell adhesion molecule, and in mice with orthotopic pancreatic tumours or patient-derived xenografts treated with T cells expressing a chimeric antigen receptor targeting mesothelin, the T cells exhibited enhanced intratumoral accumulation, exerted sustained anti-tumoral activity and prolonged animal survival only when co-expressing C-X-C chemokine receptor type 6. Arming tumour-specific T cells with tumour-specific chemokine receptors may represent a promising strategy for the realization of adoptive cell therapy for solid tumours.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
25.671
3.528
4
36
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Chimeric Antigen Receptor; Cxc Chemokine; Infiltrating Lymphocytes; Immune Cells; Immunotherapy; Cancer; Recruitment; Expression; Localization; Transduction
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Journal Nature biomedical engineering
Quellenangaben Volume: 5, Issue: 11, Pages: 1246-1260 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London ; New York NY ; Tokyo
Reviewing status Peer reviewed
Institute(s) Unit for Clinical Pharmacology (KKG-EKLiP)
Institute of Diabetes and Obesity (IDO)
Institute of Computational Biology (ICB)
POF-Topic(s) 30203 - Molecular Targets and Therapies
90000 - German Center for Diabetes Research
30205 - Bioengineering and Digital Health
Research field(s) Immune Response and Infection
Helmholtz Diabetes Center
Enabling and Novel Technologies
PSP Element(s) G-522100-001
G-501900-221
G-503800-001
Grants Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
DOI 10.1038/s41551-021-00737-6
WOS ID WOS:000657757200001
Scopus ID 85107273390
PubMed ID 34083764
Erfassungsdatum 2021-07-12
[➜Report correction]