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Genetic variation and cardiovascular risk factors: A cohort study on migrants from the former soviet union and a native german population.
Int. J. Environ. Res. Public Health 18:6215 (2021)
Resettlers are a large migrant group of more than 2 million people in Germany who migrated mainly from the former Soviet Union to Germany after 1989. We sought to compare the distribution of the major risk factors for cardiovascular disease (CVD) and to investigate the overall genetic differences in a study population which consisted of resettlers and native (autochthone) Germans. This was a joint analysis of two cohort studies which were performed in the region of Augsburg, Bavaria, Germany, with 3363 native Germans and 363 resettlers. Data from questionnaires and physical examinations were used to compare the risk factors for cardiovascular diseases between the resettlers and native Germans. A population-based genome-wide association analysis was performed in order to identify the genetic differences between the two groups. The distribution of the major risk factors for CVD differed between the two groups. The resettlers lead a less active lifestyle. While female resettlers smoked less than their German counterparts, the men showed similar smoking behavior. SNPs from three genes (BTNL2, DGKB, TGFBR3) indicated a difference in the two populations. In other studies, these genes have been shown to be associated with CVD, rheumatoid arthritis and osteoporosis, respectively.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cardiovascular Diseases ; Genetic Differences ; Germany ; Gwas ; Lifestyle ; Migrants ; Resettlers
ISSN (print) / ISBN
1661-7827
e-ISSN
1660-4601
Quellenangaben
Volume: 18,
Issue: 12,
Article Number: 6215
Publisher
MDPI
Publishing Place
Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Health Economics and Health Care Management (IGM)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Grants
Helmholtz Zentrum Munchen