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Steenblock, C.* ; Richter, S.* ; Berger, I.* ; Barovic, M. ; Schmid, J.* ; Schubert, U.* ; Jarzebska, N.* ; von Mässenhausen, A.* ; Linkermann, A.* ; Schürmann, A. ; Pablik, J.* ; Dienemann, T.* ; Evert, K.* ; Rodionov, R.N.* ; Semenova, N.Y.* ; Zinserling, V.A.* ; Gainetdinov, R.R.* ; Baretton, G.* ; Lindemann, D.* ; Solimena, M. ; Ludwig, B. ; Bornstein, S.R.*

Viral infiltration of pancreatic islets in patients with COVID-19.

Nat. Commun. 12:3534 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients. Here, we performed a comprehensive analysis of pancreatic autopsy tissue from COVID-19 patients using immunofluorescence, immunohistochemistry, RNA scope and electron microscopy and detected SARS-CoV-2 viral infiltration of beta-cells in all patients. Using SARS-CoV-2 pseudoviruses, we confirmed that isolated human islet cells are permissive to infection. In eleven COVID-19 patients, we examined the expression of ACE2, TMPRSS and other receptors and factors, such as DPP4, HMBG1 and NRP1, that might facilitate virus entry. Whereas 70% of the COVID-19 patients expressed ACE2 in the vasculature, only 30% displayed ACE2-expression in beta-cells. Even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Entry Factors; Ace2; Necroptosis; Downstream; Expression; Tmprss2; System; Mlkl
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 3534 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-001
G-502600-007
Grants Saint Petersburg State University, Saint Petersburg, Russia
DFG Heisenberg-Professorship
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
DOI 10.1038/s41467-021-23886-3
WOS ID WOS:000663747800024
Scopus ID 85107527595
PubMed ID 34112801
Erfassungsdatum 2021-07-05
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