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Early changes and indicators characterizing lung aging in neonatal chronic lung disease.
Front. Med. 8:665152 (2021)
Infants suffering from neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, are facing long-term consequences determined by individual genetic background, presence of infections, and postnatal treatment strategies such as mechanical ventilation and oxygen toxicity. The adverse effects provoked by these measures include inflammatory processes, oxidative stress, altered growth factor signaling, and remodeling of the extracellular matrix. Both, acute and long-term consequences are determined by the capacity of the immature lung to respond to the challenges outlined above. The subsequent impairment of lung growth translates into an altered trajectory of lung function later in life. Here, knowledge about second and third hit events provoked through environmental insults are of specific importance when advocating lifestyle recommendations to this patient population. A profound exchange between the different health care professionals involved is urgently needed and needs to consider disease origin while future monitoring and treatment strategies are developed.
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Publication type
Article: Journal article
Document type
Review
Keywords
Bronchopulmonary Dysplasia ; Inflammation ; Lung Aging ; Lung Function ; Mechanical Ventilation ; Neonatal Chronic Lung Disease ; Oxygen Toxicity ; Preterm Infant; Kappa-b Activation; Intrauterine Growth Restriction; Resident Alveolar Macrophages; Pulmonary Vascular-disease; Health-care Utilization; Early-onset Sepsis; Bronchopulmonary Dysplasia; Preterm Infants; Risk-factors; Recruited Monocytes
ISSN (print) / ISBN
2296-858X
e-ISSN
2296-858X
Journal
Frontiers in Medicine
Quellenangaben
Volume: 8,
Article Number: 665152
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)
Grants
doctoral study program Molecular and clinical-translational science (FoFoLe) of the Ludwig Maximilian University Munich
Research Training Group Targets in Toxicology of the German science and research organization (DFG)
German Center for Lung Research (DZL)
Helmholtz Zentrum Muenchen, Germany
Research Training Group Targets in Toxicology of the German science and research organization (DFG)
German Center for Lung Research (DZL)
Helmholtz Zentrum Muenchen, Germany